TRPA1 Agonists and Bladder Nociception in Female Rats Suggest Potential for Nutraceutical Benefit from Cinnamon

TRPA1-related drugs alter sensation, particularly in conditions of inflammation. To further characterize the role these bladder TRPA1 agonist cinnamaldehyde (CMA) and oral true cinnamon spice were examined preclinical models pain. Female adult rats, with without acute zymosan-induced cystitis, anesthetized visceromotor (VMR) cystometric responses to urinary distension (UBD) determined following either intravesical administration CMA/vehicle solutions or cinnamon/vehicle. ELISA measures content also determined. Acute cystitis resulted increases produced an increased vigor VMRs UBD a lowering micturition volume thresholds for activation response. Intravesical CMA robust inhibition rats but not those without. Micturition lowered by had no additional effect cystitis. Oral mild augmentation A potentially analgesic spice, cinnamon, treatment pain was suggested studies. Human studies are indicated.